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	Provedor de dados BJMBR (2) Autor Coimbra,T.M. (2) Costa,R.S. (2) Francescato,H.D.C. (2) Marin,E.C.S. (2) Balbi,A.P.C. (1) Chierice,J.R.A. (1) Cunha,F.Q. (1) Silva,C.G.A. (1) Mais... Palavra-chave Acute tubular necrosis (1) Angiotensin II (1) Angiotensin II antagonists (1) DL-propargylglycine (1) Gentamicin nephrotoxicity (1) Hydrogen sulfide (1) Inflammation (1) Mitogen-activated protein kinase (1) Renal development (1) Sodium intake (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Info:eu-repo/semantics/other (1) Ano 2012 (1) 2009 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Effect of endogenous hydrogen sulfide inhibition on structural and functional renal disturbances induced by gentamicin BJMBR Francescato,H.D.C.; Chierice,J.R.A.; Marin,E.C.S.; Cunha,F.Q.; Costa,R.S.; Silva,C.G.A.; Coimbra,T.M.. Animal models of gentamicin nephrotoxicity present acute tubular necrosis associated with inflammation, which can contribute to intensify the renal damage. Hydrogen sulfide (H2S) is a signaling molecule involved in inflammation. We evaluated the effect of DL-propargylglycine (PAG), an inhibitor of endogenous H2S formation, on the renal damage induced by gentamicin. Male Wistar rats (N = 8) were injected with 40 mg/kg gentamicin (im) twice a day for 9 days, some of them also received PAG (N = 8, 10 mg·kg-1·day-1, ip). Control rats (N = 6) were treated with saline or PAG only (N = 4). Twenty-four-hour urine samples were collected one day after the end of these treatments, blood samples were collected, the animals were sacrificed, and the kidneys were removed... Tipo: Info:eu-repo/semantics/other Palavras-chave: Inflammation; Gentamicin nephrotoxicity; DL-propargylglycine; Hydrogen sulfide; Acute tubular necrosis. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000300010 Roles of mitogen-activated protein kinases and angiotensin II in renal development BJMBR Balbi,A.P.C.; Francescato,H.D.C.; Marin,E.C.S.; Costa,R.S.; Coimbra,T.M.. Experimental and clinical evidence suggests that angiotensin II (AII) participates in renal development. Renal AII content is several-fold higher in newborn rats and mice than in adult animals. AII receptors are also expressed in higher amounts in the kidneys of newborn rats. The kidneys of fetuses whose mother received a type 1 AII receptor (AT1) antagonist during gestation present several morphological alterations. Mutations in genes that encode components of the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis. Morphological changes were detected in the kidneys of 3-week-old angiotensin-deficient mice. Mitogen-activated protein kinases (MAPKs) are important mediators that transduce extracellular stimuli to... Tipo: Info:eu-repo/semantics/article Palavras-chave: Renal development; Angiotensin II; Mitogen-activated protein kinase; Angiotensin II antagonists; Sodium intake. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000100007 Registros recuperados: 2 Primeira ... 1 ... Última

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